C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/712 (2006.01) C12N 5/10 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2385220
A composition comprising an antisense oligomer directed to an mRNA preferentially expressed in stem cells is described together with methods for treating stem cells with such a composition to increase the number of lineage committed progenitor cells and their progeny, and/or slow the growth of cancer cells. Also described is the use of such compositions and antisense oligonucleotide-treated stem cells as a medicament.
L'invention concerne une composition contenant un oligomère antisens dirigé sur un ARNm exprimé de préférence dans des cellules souches, ainsi que des méthodes de traitement de cellules souches à l'aide de cette composition en vue d'accroître le nombre de progéniteurs de lignée et leur descendance, et/ou de ralentir la croissance de cellules cancéreuses. L'invention concerne aussi l'utilisation, à des fins thérapeutiques, de ces compositions et de ces cellules souches traitées à l'aide d'oligonucléotides antisens.
Bartelmez Stephen H.
Iversen Patrick L.
Avi Biopharma Inc.
Gowling Lafleur Henderson Llp
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