Antisense compositions and methods for modulating contact...

Details Antisense compositions and methods for modulating contact... Antisense compositions and methods for modulating contact...

C - Chemistry, Metallurgy

12

N

C12N 15/113 (2010.01) A61K 31/712 (2006.01) A61K 31/7125 (2006.01) A61P 17/00 (2006.01)

Patent

CA 2746508

Provided are methods and compositions, including topical compositions, for inducing tolerance to a sensitizing agent known to provoke contact hypersensitivity in a subject. Included are methods of topically applying to the subject an effective amount of an antisense composition targeting the start site or splice site of a CFLAR mRNA.

La présente invention concerne des méthodes et des compositions, notamment des compositions topiques, permettant d'induire une tolérance vis-à-vis d'un agent de sensibilisation connu pour provoquer une hypersensibilité de contact chez un patient. L'invention comprend des méthodes consistant à appliquer topiquement au patient une quantité efficace d'une composition antisens ciblant le site de départ ou le site d'épissage d'un ARNm du gène CFLAR.

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