Antisense compounds directed against human csf-1

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/53 (2006.01) A61K 31/7105 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2473570

The invention concerns combination products comprising (i) at least a substance capable of inhibiting CSF-1 activity and/or at least a nucleic acid, comprising at least a sequence coding for a substance capable of inhibiting CSF-1 activity and (ii) at least a substance having a cytotoxic activity and/or at least a nucleic acid, comprising at least a sequence coding for a substance having cytotoxic activity. The invention also concerns oligonucleotides capable of inhibiting CSF-1 expression. The invention is particular useful for implementing an antitumoral treatment.

La présente invention concerne des produits de combinaison comprenant (i) au moins une substance capable d'inhiber l'activité de CSF-1 et/ou au moins un acide nucléique, comprenant au moins une séquence codant pour une substance capable d'inhiber l'activité de CSF-1 et (ii) au moins une substance ayant une activité cytotoxique et/ou au moins un acide nucléique, comprenant au moins une séquence codant pour une substance ayant une activité cytotoxique. La présente invention concerne également des oligonucléotides capables d'inhiber l'expression de CSF-1. La présente invention est particulièrement utile dans le cadre de la mise en ceuvre d'un traitement antitumoral.

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