C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2273203
The present invention provides a method for the treatment of human conditions and diseases that have an inflammatory component, including but not limited to acne, psoriasis, arthritis, transplanted organ rejection, wounds, burns, septic shock and inflammatory complications of shock. A process for selectively inhibiting the expression of the human ICAM-I, human E-selectin, or human VCAM-1 mRNA transcripts using at least one oligonucleotide which is complementary to at least a portion of the human ICAM-I, human E-selectin, or human VCAM-1 mRNAs is disclosed, as are oligonucleotides which are complementary to portions of the ICAM-I, human E-selectin, or human VCAM-1 mRNAs and compositions comprising the aforementioned oligonucleotides.
La présente invention concerne un traitement contre des maladies et des pathologies associées chez l'homme à des inflammations, à savoir, notamment l'acné, le psoriasis, l'arthrite, le rejet de greffe, les blessures, les brûlures, le choc septique et les complications inflammatoires du choc. L'invention concerne également un procédé permettant d'inhiber sélectivement l'expression des produits de transcription d'ARNm de la molécule d'adhésion intercellulaire humaine ICAM-1, de la sélectine E humaine ou de la molécule d'adhésion cellulaire vasculaire humaine VCAM-1 au moyen d'au moins un oligonucléotide complémentaire d'au moins une partie des ARNm de l'ICAM-1 humaine, de la sélectine E humaine ou de la VCAM-1 humaine. L'invention concerne en outre, non seulement des oligonucléotides complémentaires de certaines parties des ARNm de l'ICAM-1 humaine, de la sélectine E humaine ou de la VCAM-1 humaine, mais aussi des compositions comprenant ces oligonucléotides.
Bradley Matthews O.
Hoke Glenn D.
Lee Che-Hung
Williams Taffy J.
Bradley Matthews O.
Dyad Pharmaceutical Corporation
Hoke Glenn D.
Lee Che-Hung
Mcfadden Fincham
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