Antisense inhibition of ptp1b expression

Details Antisense inhibition of ptp1b expression Antisense inhibition of ptp1b expression

C - Chemistry, Metallurgy

12

N

C12N 15/113 (2010.01) A61K 31/7088 (2006.01) C12N 15/88 (2006.01) C07H 21/00 (2006.01) C12N 9/16 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2397590

Antisense compounds, compositions and methods are provided for inhibiting the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for inhibition of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.

L'invention concerne des composés antisens ainsi que des compositions et des procédés correspondants pour inhiber l'expression de PTP1B. Les compositions sont à base de composés antisens, en particulier des oligonucléotides antisens, ciblant des acides nucléiques à capacité de codage de PTP1B. L'invention concerne en outre des procédés relatifs à l'utilisation des composés considérés pour inhiber l'expression de PTP1B et pour traiter les maladies associées à l'expression de PTP1B.

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