Antisense inhibitors of the human immunodeficiency virus

Details Antisense inhibitors of the human immunodeficiency virus Antisense inhibitors of the human immunodeficiency virus

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 31/70 (2006.01) C07K 14/16 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2082631

2082631 9118004 PCTABS00008 Methods for modulating the expression of the HIV tat gene are disclosed comprising contacting tat RNA with oligonucleotide or oligonucleotide analog which can bind with at least a portion of the RNA. In accordance with the preferred embodiments, oligonucleotides or oligonucleotide analogs are designed to bind to portions of the tat RNA which are of significance to the expression of the gene coding for said RNA. In accordance with a preferred embodiment, methods of treatment of human immunodeficiency virus are disclosed.

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