C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/02 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12P 19/34 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2495037
Antisense compounds, compositions, and methods are provided for modulating the expression of acyl-Coa synthesis 1, heretofore referred to as ACS1. The compositions comprise antisense compounds, particulary antisense oligonucleotides, targeted to nucleic acids encoding ACS1. Methods of using these compounds for modulation of ACS1 expression and for treatment of diseases associated with expression of ACS1 are provided.
La présente invention concerne des composés antisens, des compositions et des méthodes permettant de moduler l'expression de l'acyl-CoA synthétase 1, jusqu'ici appelée ACS1. Lesdites compositions comprennent des composés antisens, notamment des oligonucléotides antisens, ciblés sur des acides nucléiques codant pour l'ACS1. L'invention concerne des méthodes d'utilisation desdits composés pour la modulation de l'expression de l'ACS1 et pour le traitement de maladies associées à l'expression de l'ACS1.
Pharmacia Corporation
Smart & Biggar
LandOfFree
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