Antisense modulation of apolipoprotein(a) expression

Details Antisense modulation of apolipoprotein(a) expression Antisense modulation of apolipoprotein(a) expression

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A01N 43/04 (2006.01) A61K 31/07 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2455498

Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein(a). Methods of using these compounds for modulating of apolipoprotein(a) expression and for treatment of diseases associated with expression of apolipoprotein(a) are provided.

L'invention concerne des composés antisens, des compositions et des procédés destinés à moduler l'expression de l'apolipoprotéine (a). Lesdites compositions comprennent des composés antisens, en particulier des oligonucléotides antisens, ciblés sur des acides nucléiques codant l'apolipoprotéine (a). L'invention concerne également des procédés d'utilisation desdits composés pour la modulation de l'expression de l'apolipoprotéine (a), et pour le traitement de maladies associées à l'expression de l'apolipoprotéine (a).

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