Antisense modulation of apolipoprotein b expression

Details Antisense modulation of apolipoprotein b expression Antisense modulation of apolipoprotein b expression

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2455228

Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided.

Cette invention concerne des composés antisens, des compositions ainsi que des procédés servant à moduler l'expression de l'apolipoprotéine B. Ces compositions renferment des composés antisens, en particulier des oligonucléotides antisens, visant des acides nucléiques codant l'apolipoprotéine B. Cette invention concerne également des méthodes d'utilisation de ces composés pour la modulation de l'expression de l'apolipoprotéine B et pour le traitement de maladies associées à l'expression de l'apolipoprotéine B.

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