Antisense modulation of apolipoprotein b expression

A - Human Necessities – 61 – K

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Details

A61K 48/00 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2505801

Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided.

L'invention concerne des composés, des compositions et des procédés antisens permettant de moduler l'expression d'apolipoprotéine B. Ces compositions comprennent des composés antisens, en particulier des oligonucléotides antisens, ciblés à des acides nucléiques codant apolipoprotéine B. L'invention concerne des procédés d'utilisation de ces composés de modulation de l'expression d'apolipoprotéine B et des procédés de traitement de maladies associées à l'expression d'apolipoprotéine B.

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