Antisense modulation of bcl-x expression

Details Antisense modulation of bcl-x expression Antisense modulation of bcl-x expression

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/02 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2345354

Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x expression and for treatment of diseases associated with expression of bcl-x are also provided. Methods of sensitizing cells to apoptotic stimuli are also provided.

L'invention concerne des compositions et des procédés permettant de moduler l'expression du gène bcl-x. On utilise de préférence des composés antisens, en particulier des oligonucléotides antisens, ciblés sur les acides nucléiques codant le gène bcl-x. L'invention concerne également des procédés relatifs à l'utilisation de ces composés, pour la modulation de l'expression du bcl-x et pour le traitement des maladies associées à l'expression dudit bcl-x. L'invention concerne en outre des procédés qui permettent de sensibiliser les cellules aux stimuli de l'apoptose.

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