Antisense modulation of cellular inhibitor of apoptosis-1...

Details Antisense modulation of cellular inhibitor of apoptosis-1... Antisense modulation of cellular inhibitor of apoptosis-1...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2353090

Antisense compounds, compositions and methods are provided for modulating the expression of Cellular Inhibitor of Apoptosis-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Cellular Inhibitor of Apoptosis-1. Methods of using these compounds for modulation of Cellular Inhibitor of Apoptosis-1 expression and for treatment of diseases associated with expression of Cellular Inhibitor of Apoptosis-1 are provided.

Cette invention concerne des composés antisens ainsi que des compositions et des procédés qui permettent de moduler l'expression de l'inhibiteur cellulaire de l'apoptose-1. Ces compositions contiennent des composés antisens, notamment des oligonucléotides antisens, qui sont ciblés vers les acides nucléiques codant l'inhibiteur cellulaire de l'apoptose-1. Cette invention concerne également des procédés d'utilisation de ces composés afin de moduler l'expression de l'inhibiteur cellulaire de l'apoptose-1, et afin de traiter des maladies associées à l'expression de l'inhibiteur cellulaire de l'apoptose-1.

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