A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7115 (2006.01) A61K 31/712 (2006.01) A61K 31/7125 (2006.01) C07H 21/00 (2006.01) C12N 5/06 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2397202
Antisense compounds, compositions and methods are provided for modulating the expression of glycogen synthase kinase 3 alpha. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding glycogen synthase kinase 3 alpha. Methods of using these compounds for modulation of glycogen synthase kinase 3 alpha expression and for treatment of diseases associated with expression of glycogen synthase kinase 3 alpha are provided.
La présente invention concerne des composés antisens, des compositions et des méthodes de modulation de l'expression de glycogène synthase kinase 3 alpha. Ces compositions renferment des composés antisens, notamment des oligonucléotides antisens, des acides nucléiques ciblés codant la glycogène synthase kinase 3 alpha. Cette invention concerne aussi des méthodes d'utilisation de ces composés pour moduler l'expression de la glycogène synthase kinase 3 alpha et traiter des maladies liées à l'expression de la glycogène synthase kinase 3 alpha.
Butler Madeline M.
Mckay Robert
Monia Brett P.
Wyatt Jacqueline R.
Borden Ladner Gervais Llp
Isis Pharmaceuticals Inc.
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