Antisense modulation of hormone-sensitive lipase expression

Details Antisense modulation of hormone-sensitive lipase expression Antisense modulation of hormone-sensitive lipase expression

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A01N 43/04 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) C12P 19/34 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2453894

Antisense compounds, compositions and methods are provided for modulating the expression of hormone-sensitive lipase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding hormone-sensitive lipase. Methods of using these compounds for modulation of hormone-sensitive lipase expression and for treatment of diseases associated with expression of hormone-sensitive lipase are provided.

L'invention concerne des composés antisens, des compositions et des méthodes permettant de moduler l'expression d'une lipase sensible aux hormones. Ces compositions comprennent des composé antisens, et notamment des oligonucléotides antisens, ciblés sur des acides nucléiques codant pour une lipase sensible aux hormones. L'invention concerne en outre des méthodes d'utilisation de ces composés pour moduler l'expression d'une lipase sensible aux hormones et pour traiter des maladies associées à l'expression de cette lipase sensible aux hormones.

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