Antisense modulation of human mdm2 expression

Details Antisense modulation of human mdm2 expression Antisense modulation of human mdm2 expression

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2322773

Compounds, compositions and methods are provided for inhibiting the expression of human mdm2. The compositions include antisense compounds targeted to nucleic acids encoding mdm2. Methods of using these oligonucleotides for inhibition of mdm2 expression and for treatment of diseases such as cancers associated with overexpression of mdm2 are provided.

L'invention concerne des composés, des compositions et des procédés qui inhibent l'expression du gène mdm2 humain. Les compositions comprennent notamment des composés antisens qui ciblent des acides nucléiques codant pour mdm2. L'invention concerne des procédés d'utilisation de ces oligonucléotides pour inhiber l'expression de mdm2 et pour traiter des maladies, tels des cancers, associées à une surexpression de mdm2.

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