Antisense modulation of insulin-like growth factor 2 expression

C - Chemistry – Metallurgy – 07 – H

Patent

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C07H 21/02 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12N 15/86 (2006.01) C12P 19/34 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2491497

Antisense compounds, compositions and methods are provided for modulating the expression of insulin-like growth factor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding insulin-like growth factor 2. Methods of using these compounds for modulation of insulin-like growth factor 2 expression and for treatment of diseases associated with expression of insulin-like growth factor 2 are provided.

Cette invention concerne des compos~s antisens, des compositions et des m~thodes permettant de moduler l'expression du facteur de croissance de type insuline de type 2. Les compositions comprennent des compos~s antisens, en particulier des oligonucl~otides antisens, cibl~s sur des acides nucl~iques qui codent pour le facteur de croissance de type insuline de type 2. L'invention concerne ~galement des m~thodes d'utilisation de ces compos~s pour la modulation de l'expression du facteur de croissance de type insuline de type 2 et pour le traitement de maladie associ~es ~ l'expression dudit facteur de croissance.

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