Antisense modulation of integrin .alpha.4 expression

Details Antisense modulation of integrin .alpha.4 expression Antisense modulation of integrin .alpha.4 expression

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2345209

Compositions and methods are provided for modulating the expression of integrin .alpha.4. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding integrin .alpha.4 are preferred. Methods of using these compounds for modulating integrin .alpha.4 expression and for treatment of diseases associated with expression of integrin .alpha.4 are also provided.

L'invention concerne des compositions et des procédés pour la modulation de l'expression de l'intégrine .alpha.4. Des composés antisens, notamment des oligonucléotides antisens, dirigés sur des acides nucléiques codant l'intégrine .alpha.4 sont préférés. Des procédés d'utilisation de ces composés, pour la modulation de l'expression de l'intégrine .alpha.4 et pour le traitement de maladies associées à l'expression de l'intégrine .alpha.4, sont également décrits.

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