C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 35/00 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2397205
Antisense compounds, compositions and methods are provided for modulating the expression of Macrophage migration inhibitory factor. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Macrophage migration inhibitory factor. Methods of using these compounds for modulation of Macrophage migration inhibitory factor expression and for treatment of diseases associated with expression of Macrophage migration inhibitory factor are provided.
L'invention concerne des composés antisens, des compositions et des procédés destinés à moduler l'expression du facteur inhibiteur de migration du macrophage. Les compositions comprennent des composés antisens, en particulier des oligonucléotides antisens, dirigés vers des acides nucléiques codant pour le facteur d'inhibition de migration du macrophage. L'invention concerne aussi des méthodes d'utilisation de ces composés pour la modulation de l'expression du facteur d'inhibition du macrophage et pour le traitement de maladies associées à l'expression de ce facteur.
Cowsert Lex M.
Murray Susan F.
Wyatt Jacqueline R.
Borden Ladner Gervais Llp
Isis Pharmaceuticals Inc.
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