C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2504357
Antisense compounds, compositions, and methods are provided for modulating the expression of a family of polypeptides from mitochondrial membranes, which bind insulin sensitizing, antidiabetic thiazolodinediones (mitoNEET). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding mitoNEET. Methods of using these compounds for modulation of mitoNEET expression and for treatment of diseases associated with expression of mitoNEET are provided.
L'invention concerne des composés anti-sens, des compositions et des méthodes destinés à la modulation de l'expression d'une famille de polypeptides issus de membranes mitochondriales, qui fixent les thiazolidinediones antidiabétiques insulino-sensibilisantes (mitoNEET). Ces compositions comprennent des composés anti-sens et plus particulièrement des oligonucléotides anti-sens, dirigés contre des acides nucléiques codant pour mitoNEET. L'invention concerne également des méthodes d'utilisation de ces composés pour moduler l'expression de mitoNEET et pour traiter des maladies associées à l'expression de mitoNEET.
Pharmacia Corporation
Sim & Mcburney
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