Antisense modulation of nav1.3 expression

Details Antisense modulation of nav1.3 expression Antisense modulation of nav1.3 expression

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2495398

Antisense compounds, compositions, and methods are provided for modulating the expression of Type III sodium channel Nav1.3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Nav1.3. Methods of using these compounds for modulation of Nav1.3 expression and for treatment of diseases associated with expression of Nav1.3 are provided.

L'invention concerne des composés, des compositions et des procédés antisens destinés à moduler l'expression de Nav1.3 de canal de sodium de type III. Ces compositions contiennent des composés antisens, notamment des oligonucléotides antisens, ciblés vers des acides nucléiques codant Nav1.3. Les procédés de l'invention utilisent ces composés en vue de moduler l'expression de Nav1.3 et en vue de traiter des maladies associées à l'expression de Nav1.3.

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