Antisense modulation of ptp1b expression

Details Antisense modulation of ptp1b expression Antisense modulation of ptp1b expression

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A01N 43/04 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12P 19/34 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2447004

Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.

Cette invention concerne des composés, des compositions et des méthodes permettant de moduler l'expression de PTP1B. Les compositions comprennent des composés antisens, en particulier des olignucléotides antisens, ciblés sur des acides nucléiques qui codent pour PTP1B. L'invention concerne également des composés convenant pour la modulation de l'expression de PTP1B et pour l'expression de pathologies en rapport avec l'expression de PTP1B.

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