C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/02 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2451643
Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismutase 1, soluble. Methods of using these compounds for modulation of superoxyde dismutase 1, soluble expression and for treatment of diseases associated with expression of superoxide dismutase 1, soluble are provided.
L'invention concerne des composés anti-sens, des compositions et des procédés associés permettant de moduler l'expression de la superoxyde dismutase 1 soluble. Les compositions renferment des composés anti-sens, notamment des oligonucléotides anti-sens, ciblés sur des acides nucléiques codant la superoxyde dismutase 1 soluble. L'invention concerne également des procédés d'utilisation de ces composés aux fins de modulation de l'expression de la superoxyde dismutase 1 soluble et de traitement de maladies associées avec l'expression de la superoxyde dismutase 1 soluble.
Bennett C. Frank
Dobie Kenneth
Borden Ladner Gervais Llp
Isis Pharmaceuticals Inc.
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