A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/712 (2006.01)
Patent
CA 2331333
The present invention relates to modified oligonucleotide therapeutic agents to selectively prevent gene transcription and expression in a sequence-specific manner. In particular, this invention relates to the selective inhibition of protein biosynthesis via antisense strategy using oligonucleotides constructed from arabinonucleotide or modified arabinonucleotide residues. More particularly this invention relates to the use of antisense oligonucleotides having arabinose sugars to hybridize to complementary RNA such as cellular messenger RNA, viral RNA, etc.
La présente invention concerne des agents thérapeutiques oligonucléotides modifiés de façon à prévenir la transcription et l'expression génique d'une façon spécifique d'une séquence. L'invention concerne notamment une inhibition sélective de la biosynthèse des protéines en recourant à une stratégie antisense mettant en oeuvre des oligonucléotides construits à partir d'arabinonucléotides ou de restes d'arabinonucléotides modifiés. L'invention concerne plus particulièrement l'utilisation d'oligonucléotides antisense comportant des sucres, en l'occurrence des arabinoses, capables de s'hybrider avec de l'ARN complémentaire tel que notamment l'ARN messager cellulaire et l'ARN viral.
Arion Dominique
Borkow Gadip
Damha Massad Jose
Noronha Anne M.
Parniak Michael A.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
University Mcgill
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