C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2173361
The present invention encompasses improved methods and materials for the delivering of antisense, triplex, and/or ribozyme oligonucleotides intracellularly, and RNA polymerase III-based constructs termed "oligonucleotide generators" to accomplish the delivery. of oligonucleotides. Also encompassed by the present invention are methods for screening oligonucleotide sequences that are candidates for triplex formation.
La présente invention se rapporte à des procédés et matières améliorés destinés à l'apport intracellulaire d'oligonucléotides anti-sens, d'oligonucléotides triplex et/ou de ribozymes, ainsi qu'à des structures basées sur de l'ARN-polymérase III, appelées "générateurs d'oligonucléotides", lesquels exécutent l'apport des oligonucléotides. L'invention se rapporte également à des procédés de criblage de séquences d'oligonucléotides susceptibles de former des triplex.
Hunt C. Anthony
Noonberg Sarah B.
Smart & Biggar
The Regents Of The University Of California
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