Antisense oligonucleotide inhibition of papillomavirus

Details Antisense oligonucleotide inhibition of papillomavirus Antisense oligonucleotide inhibition of papillomavirus

C - Chemistry, Metallurgy

12

N

C12N 15/37 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 14/025 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2070664

Oligonucleotides and oligonucleotide analogs are provided which are capable of antisense interaction with messenger RNA of papillomavirus. Such oligonucleotides or oligonucleotide analogs can be used for diagnostics and therapeutics as well as for research purposes. In accordance with preferred embodiments of this invention, oligonucleotide or oligonucleotide analog is provided which is hybridizable with a messenger RNA from a papillomavirus. The oligonucleotide or oligonucleotide analog is able to inhibit the function of the RNA; and accordingly is useful for therapy for infections by such papillomavirus. In accordance with a preferred embodiment, portions of the papillomavirus are targeted for antisense attack. Thus oligonucleotides are preferably provided which hybridize with the E2; E1, E7, or E6-7 messenger RNAs.

Oligonucléotides et analogues oligonucléotidiques pouvant avoir une action réciproque non codante avec l'ARN messager du virus du papillome. De tels oligonucléotides ou analogues oligonucléotidiques peuvent servir au diagnostic et à la thérapeutique ainsi qu'à des fins de recherche. Selon des modes de réalisation préférés, l'oligonucléotide ou l'analogue oligonucléotidique est hybridable avec un ARN messager provenant d'un virus du papillome, peut inhiber la fonction de l'ARN, et est donc utile à la thérapie des infections provoquées par un tel virus du papillome. Selon un mode de réalisation préféré, on cible des parties du virus du papillome pour une attaque non codante. On peut donc obtenir les oligonucléotides préférables, c'est-à-dire ceux qui s'hybrident avec les ARN messagers E2, E1, E7, ou E6-7.

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