C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/70 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2167680
Vascular Endothelial Growth Factor (VEGF), also known as vascular permeability factor (VPF), has been shown to play in integral role in abnormal angiogenesis associated with a variety of pathological states. This disclosure presents compounds, compositions, and methods for inhibiting such abnormal angiogenesis. In particular, this disclosure presents several antisense oligonucleotides from 19 to 21 bases long that bind to VEGF RNA and inhibit production of the expression product. These antisense oligonucleotides are useful in the treatment of pathological states in which VEGF expression plays a role.
On a démontré que le facteur de croissance endothéliale vasculaire (VEGF), également appelé facteur de perméabilité vasculaire (VPF), joue à part entière un rôle dans l'angiogenèse anormale associée à divers états pathologiques. L'exposé concerne des composés, compositions et procédés permettant d'inhiber cette angiogenèse anormale. Cet exposé concerne notamment plusieurs oligonucléotides antisens, longs de 19 à 21 bases, qui se lient à l'ARN du VEGF et inhibent la production du produit d'expression. Ces oligonucléotides antisens se révèlent utiles dans le traitement d'états pathologiques où l'expression du VEGF joue un rôle.
Hybridon Inc.
Mbm Intellectual Property Law Llp
LandOfFree
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