Antisense oligonucleotide modulation of tumor necrosis...

Details Antisense oligonucleotide modulation of tumor necrosis... Antisense oligonucleotide modulation of tumor necrosis...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2344616

Compositions and methods are provided for inhibiting the expression of human tumor necrosis factor-.alpha. (TNF-.alpha.). Antisense oligonucleotides targeted to nucleic acids encoding TNF-.alpha. are preferred. Methods of using these oligonucleotides for inhibition of TNF-.alpha. expression and for treatment of diseases, particularly inflammatory and autoimmune diseases, associated with overexpression of TNF-.alpha. are provided.

L'invention se rapporte à des compositions et des procédés pour inhiber l'expression du facteur de nécrose tumorale alpha (TNF-alpha). Des oligonucléotides antisens ciblés sur des acides nucléiques codant le TNF-alpha sont préférés. On décrit des procédés d'utilisation desdits oligonucléotides pour inhiber l'expression du TNF-alpha et pour traiter des maladies, notamment des maladies inflammatoires ou auto-immunes, associées à la surexpresssion du TNF-alpha.

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