C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) C12N 9/16 (2006.01) C12N 15/55 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2563741
Antisense oligonucleotides against cPLA2 are provided, which are capable of inhibiting cPLA2 expression as well as superoxide production, especially in phagocytes. These antisense oligonucleotides are powerful agents for the treatment of inflammatory conditions, in particular arthritis, as well as in neurodegenerative diseases. The antisense oligonucleotides or compositions comprising the same may be used in methods of treatment of such diseases.
Des oligonucléotides antisens dirigés contre cPLA¿2? aptes à inhiber l'expression de cPLA¿2? ainsi que la production de superoxyde, notamment dans les phagocytes. Les oligonucléotides antisens sont des agents puissants de traitement de pathologies inflammatoires, plus particulièrement de l'arthrite, ainsi que des maladies neurodégénératives. Les oligonucléotides antisens ou les compositions les comprenant peuvent servir dans des méthodes de traitement de telles maladies.
Ben-Gurion University Of The Negev Research And Development Auth
Goudreau Gage Dubuc
Mor - Research Applications Ltd.
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