Antisense oligonucleotides against hepatitis b viral...

Details Antisense oligonucleotides against hepatitis b viral... Antisense oligonucleotides against hepatitis b viral...

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 31/70 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2196070

Antisense oligonucleotides that hybridize to segments of the preS1, S, C, and epsilon regions of the hepatitis B virus (HBV) RNA pregenome inhibit replication of the virus. The figure illustrates the relative positions of antisense oligonucleotides targeted against the HBV S gene. Pharmaceutical compositions which contain these oligonucleotides as the active ingredients are effective against HBV infection.

Des oligonucléotides antisens s'hybridant à des segments des régions preS1, S, C et epsilon du prégénome de l'ARN du virus de l'hépatite B (HBV) inhibent la réplication de ce virus. La figure illustre les positions relatives d'oligonucléotides antisens ciblés contre le gène S de HBV. Des compositions pharmaceutiques contenant ces oligonucléotides en tant qu'ingrédients actifs sont efficaces contre l'infection par HBV.

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