Antisense oligonucleotides directed against connective...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/113 (2010.01) A61K 31/7088 (2006.01) A61K 31/7125 (2006.01) A61K 31/713 (2006.01) A61P 17/00 (2006.01) A61P 17/02 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2733262

This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue growth factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.

La présente invention concerne des composés qui comprennent des oligonucléotides modifiés capables d'une expression inhibitrice du facteur de croissance des tissus conjonctifs et une composition contenant ces composés ainsi que les procédés de traitement de troubles hyperprolifératifs et de maladies fibreuses, et de réduction de cicatrice résultant d'une cicatrisation au moyen de ces composés.

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