Antisense oligonucleotides directed to ribonucleotide...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) C12N 9/02 (2006.01)

Patent

CA 2526393

The present invention provides antisense oligonucleotides directed to a mammalian ribonucleotide reductase R1 gene and combinations of the antisense oligonucleotides with one or more chemotherapeutic agents for use in the treatment of cancer.

La présente invention concerne des oligonucléotides antisens dirigés contre un gène R1 de la ribonucléotide réductase de mammifères ainsi que des associations desdits oligonucléotides antisens avec un ou plusieurs agents chimiothérapeutiques destinés à être utilisés dans le traitement du cancer.

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