Antisense oligonucleotides for inhibiting helicobacter...

Details Antisense oligonucleotides for inhibiting helicobacter... Antisense oligonucleotides for inhibiting helicobacter...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2215449

Antisense oligonucleotides that selectively hybridise with one or more genes necessary for Helicobacter pylori (H. pylori) activity, and particularly with the CagA cytotoxicity-associated immunodominant antigen, flagellin (flaA and flaB) or vacuolating cytotoxin (vacA), are disclosed. Pharmaceutical compositions containing said antisense oligonucleotides, and the use thereof for treating atrophic gastritis, peptic and duodenal ulcers, gastric atrophy or stomach cancer, are also disclosed.

La présente invention concerne des oligonucléotides antisens qui hybrident sélectivement avec un ou plusieurs gènes nécessaires à l'action de l'Helicobacter pylori (H pylori), en particulier avec l'antigène immuno-dominant associé à la cytotoxicité CagA, la flagelline (flaA et flaB) ou la cytotoxine vacuolante (vacA). L'invention concerne aussi des compositions pharmaceutiques contenant ces antisens et leur utilisation dans le traitement de gastrique atrophique, d'ulcère peptique et duodénal, d'atrophie gastrique ou de carcinome gastrique.

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