C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/00 (2006.01) A61K 31/711 (2006.01) A61P 35/04 (2006.01) C07H 21/00 (2006.01)
Patent
CA 2538883
Described are antisense oligonucleotides targeted to the gene encoding osteopontin, bone sialoprotein II and/or osteonectin, wherein said oligonucleotides inhibit the expression of said gene(s). Moreover, the therapeutic use of said antisense oligonucleotides is described, e.g., for the treatment or prevention of cancer/metastasis, preferably osteolytic metastasis or metastasis of breast cancer cells.
L'invention concerne des oligonucléotides antisens dirigés contre le gène codant l'ostéopontine, la sialoprotéine osseuse II et/ou l'ostéonectine, ces oligonucléotides inhibant l'expression dudit ou desdits gènes. L'invention concerne en outre l'utilisation thérapeutique desdits oligonucléotides antisens, par exemple pour le traitement ou la prévention de cancers/métastases, de préférence de métastases ostéolytiques ou de métastases de cellules du cancer du sein.
Adwan Hassan
Armbruster Franz
Baeuerle Tobias
Berger Martin
Armbruster Biotechnology Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Deutsches Krebsforschungszentrum
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