Antisense oligonucleotides for treating or preventing atopic...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) A61K 31/70 (2006.01) C07H 21/04 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2330545

The present invention relates to the use of antisense oligonucleotides directed against specific nucleic acid sequences coding for receptors, alone or in combination, in order to inhibit the inflammatory reaction that is present in asthma, atopy or hypereosinophilia and to inhibit neoplastic cell proliferation. The antisense oligonucleotides of the present invention are used for treating and/or preventing asthma, allergy, hypereosinophilia, general inflammation or cancer. The oligonucleotides of the present invention are more specifically directed against nucleic acid sequences coding for a CCR3 receptor, a common sub-unit of IL-4 and IL-13 receptors, or a common sub-unit of IL-3, IL-5 and GM-CSF receptors.

L'invention concerne l'utilisation d'oligonucléotides antisens dirigés contre des séquences d'acides nucléiques spécifiques qui codent pour des récepteurs, seuls ou en combinaison, afin d'inhiber la réaction inflammatoire présente dans l'asthme, l'atopie ou l'hyperéosinophilie, et pour inhiber une prolifération de cellules néoplasiques. Les oligonucléotides antisens de l'invention sont utilisés pour traiter et/ou prévenir l'asthme, des allergies, l'hyperéosinophilie, une inflammation générale ou le cancer. Les oligonucléotides de l'invention sont plus spécifiquement dirigés contre des séquences d'acides nucléiques qui codent pour un récepteur de CCR3, pour une sous-unité commune de récepteurs d'IL-4 et d'IL-13, ou pour une sous-unité commune de récepteurs d'IL-3, d'IL-5 et du GM-CSF.

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