C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2177732
The invention encompasses tumorigenicity-inhibiting antisense oligonucleotide sequences complementary to mRNA or double-stranded DNA that encodes mammalian DNA methyl transferase. It further encompasses methods for inhibiting tumorigenicity and pharmaceutical composition comprising the tumorigenicity-inhibiting antisense nucleotide.
L'invention se rapporte à des séquences oligonucléotidiques antisens, inhibant l'oncogénécité, complémentaires à un ARNm ou un ADN double-brin codant l'ADN méthyl transférase de mammifère. L'invention se rapporte en outre à des procédés permettant d'inhiber l'oncogénicité, ainsi qu'à une composition pharmaceutique comprenant le nucléotide antisens inhibant l'oncogénicité.
Hofe Eric von
Szyf Moshe
Hybridon Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
University Mcgill
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