Antisense oligonucleotides of pleiotrophin

Details Antisense oligonucleotides of pleiotrophin Antisense oligonucleotides of pleiotrophin

A - Human Necessities

61

K

A61K 31/70 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2195450

Antisense oligonucleotides that hybridize to segments of the mRNA corresponding to the cDNA for pleiotrophin inhibit synthesis of pleiotrophin in vitro and in vivo. Pharmaceutical compositions containing these oligonucleotides as the active ingredients also are disclosed.

Des oligonucléotides antisens s'hybridant à des segments de l'ARNm correspondant à l'ADNc pour la pléiotrophine inhibent la synthèse de cette dernière in vitro et in vivo. Sont également décrites des compositions pharmaceutiques contenant ces oligonucléotides comme principes actifs.

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