Antisense oligonucleotides to c-abl proto-oncogene

Details Antisense oligonucleotides to c-abl proto-oncogene Antisense oligonucleotides to c-abl proto-oncogene

A - Human Necessities

61

K

A61K 48/00 (2006.01) C07K 14/82 (2006.01) C12N 9/12 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2065294

2065294 9103260 PCTABS00003 Oligonucleotides are provided having a nucleotide sequence complementary to at least a portion of the mRNA transcript of the human c-abl gene. These ''antisense'' oligonucleotides are hybridizable to the c-abl mRNA transcript. Such oligonucleotides are useful in inhibiting proliferation of myeloid cells, particularly in myelo-proliferative disorders such as chronic myelogenous leukemia.

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