Antisense oligonucleotides to c-myb proto-oncogene and uses...

Details Antisense oligonucleotides to c-myb proto-oncogene and uses... Antisense oligonucleotides to c-myb proto-oncogene and uses...

C - Chemistry, Metallurgy

07

H

167/202, 167/5.1

C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 35/28 (2006.01) C07H 21/04 (2006.01)

Patent

CA 1340369

Oligonucleotides are provided having a nucleotide sequence complementary to at least a portion of the mRNA transcript of the human c-myb gene. These "antisense" oligonucleotides are hybridizable to the c-myb mRNA transcript. Such oligonucleotides are useful in treating hematologic neoplasms and in inducing immunosuppression. They are particularly useful as bone marrow purging agents.

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