Antisense oligonucleotides to inhibit expression of mutated...

Details Antisense oligonucleotides to inhibit expression of mutated... Antisense oligonucleotides to inhibit expression of mutated...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2148687

2148687 9411494 PCTABS00032 The invention is an oligonucleotide substantially complementary to a mutant collagen nucleotide sequence and not perfectly complementary to a wild type collagen nucleotide sequence, methods for selecting and preparing such an oligonucleotide, and methods for treating mammals having diseases exhibiting mutant collagen gene expression using such an oligonucleotide to inhibit mutant collagen gene expression.

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