C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61P 9/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2451874
The invention relates to pharmaceutical compositions which inhibit the formation of capillary tubes by endothelial cells, comprising at least one oligonucleotide which can inhibit the expression of the IRS-1 protein. According to the invention, the oligonucleotides are embodied as anti-angiogenesis agents. Said pharmaceutical compositions are particularly useful in treating angiogenesis-related pathologies.
La présente invention a pour objet des compositions pharmaceutiques pour inhiber la formation de tubes capillaires par les cellules endothéliales, comprenant au moins un oligonucléotide capable d'inbiher l'expression de la protéine IRS-1. Les oligonucléotides selon l'invention sont indiqués comme agents anti-angiogéniques. Les compositions pharmaceutiques de l'invention sont particulièrement utiles pour le traitement de pathologies liées à l'angiogénèse.
Gene Signal
Gene Signal International Sa
Gowling Lafleur Henderson Llp
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