C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2158834
Compositions and methods for achieving therapeutic treatment of diseases and for regulating gene expression in biological experimental systems via interference with 5' capping of targeted nascent mRNAs are disclosed. Interference with capping is achieved in accordance with preferred embodiments utilizing antisense oligonucleotide compounds which are complementary to the targeted nascent RNA and prevent binding of capping enzyme either via steric interference or by chemical modification of the nascent mRNA.
Isis Pharmaceuticals Inc.
Isis Pharmaceuticals Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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