Antithrombin composition and process for preparation thereof

A - Human Necessities – 61 – K

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A61K 31/445 (2006.01) A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 9/107 (2006.01) A61K 31/47 (2006.01) A61K 31/535 (2006.01) A61K 47/12 (2006.01)

Patent

CA 2114152

ABSTRACT OF THE DISCLOSURE An antithrombin composition in the form of emulsion which comprises, together with a slovent, a diluent, and an emulsifier, N2-arylsulfonyl-L-arginineamide represented by the general formula (I): Image ... (I) wherein R1 represents (2R,4R)-4-alkyl-2-carboxypiperidino group, R2 represents phenyl group or a condensed polycyclic compound residue as defined below, and said R2 optionally has one or more substituents selected from lower alkyl group, lower alkoxy group or amino group substituted by lower alkyl group, said condensed polycyclic compound residue being a condensed polycyclic compound residue including a benzene ring, said benzene ring being bound to the sulfur atom of the sulfonyl group in the general formula (I) and said benzene ring being condensed with other ring which may be a heterocyclic ring, and said polycyclic compound residue having 7 - 14 carbon atoms in total, its hydrate and/or its salt, is provided. - 19 -

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