Antithrombin nucleotides and proteins from horn fly

Details Antithrombin nucleotides and proteins from horn fly Antithrombin nucleotides and proteins from horn fly

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) A61K 38/48 (2006.01) A61K 38/57 (2006.01) C07K 14/81 (2006.01) C07K 16/38 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2339870

Compositions and methods for preventing hematophagous infestation of cattle are provided, directed at isolated proteins with antithrombin activity and nucleotide sequences encoding the proteins. The proteins named thrombostasin is isolated from the salivary glands of Haematobia irritans. The compositions are useful as veterinary vaccines in prevention of blood-feeding in cattle by the infesting horn fly. The proteins of the invention are also useful in treatment of thrombosis.

L'invention concerne des compositions et des procédés destinés à empêcher une infestation hématophage du bétail et ciblant des protéines isolées à activité antithrombotique et des séquences nucléotidiques codant pour ces protéines. La protéine, désignée thrombostasine, est isolée à partir des glandes salivaires de Haematobia irritans. Les compositions peuvent servir comme des vaccins vétérinaires aidant la prévention de l'activité sanguinivore de la mouche des cornes infestant le bétail. Les protéines de l'invention servent également à traiter la thrombose.

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