Antithrombogenic membrane mimetic compositions and methods

A - Human Necessities – 61 – L

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A61L 33/00 (2006.01) A61L 15/32 (2006.01) A61L 27/22 (2006.01) A61L 27/24 (2006.01) A61L 27/50 (2006.01) C07F 9/10 (2006.01) C07F 9/655 (2006.01)

Patent

CA 2406343

The present Specification describes materials and methods which provide for improved performance of medical prostheses, including vascular graft material, artificial heart valves, and other implanted materials. The materials comprising bound thrombomodulin or a functionally equivalent derivative protein, provide for fewer undesirable side effects including inflammation, thromboses and neointimal hyperplasia.

L'invention concerne des matériaux et des procédés permettant d'améliorer les performances de prothèses médicales, par exemple les matériaux de greffe vasculaire, les valvules cardiaques artificielles, et d'autres matériaux implantés. Ces matériaux comprenant de la thrombomoduline liée ou une protéine dérivée, fonctionnellement équivalente, provoquent peu d'effets secondaires indésirables, tels que les inflammations, les thromboses et l'hyperplasie néo-intimale.

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