Antithrombosis agents

Details Antithrombosis agents Antithrombosis agents

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 38/36 (2006.01) A61K 38/55 (2006.01) C07K 14/745 (2006.01) C07K 14/81 (2006.01) C12N 9/64 (2006.01) C12P 21/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2090410

2090410 9204378 PCTABS00011 Analogs of Factor Xa (Factor Xai) which are inactive as proteases in the prothrombinase reaction are useful in treatment of diseases characterized by thrombosis. These antithrombotic agents can be conveniently prepared using recombinant techniques. In addition, modified forms of Factor Xa that generate Factor Xa in serum but have extended half-lives are useful in treating hemophilic conditions. These modified forms of Factor Xa are typically acylated forms of the serine residue in the active site which are slowly deacylated in vivo.

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