C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/18 (2006.01) A61K 39/395 (2006.01) A61P 7/02 (2006.01) C07K 16/36 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2206423
A monoclonal antibody, which has reactivity with human von Willebrand factor, which has action to inhibit RIPA (ristocetin-induced platelet aggregation), BIPA (botrocetin-induced platelet aggregation), and SIPA (shear stress-induced platelet aggregation) of human platelet, and which does not express bleeding action in an medicinally effective dose to exhibit antithrombotic action, is used as an active ingredient of an antithrombotic agent.
Cette invention se rapporte à un agent antithrombotique contenant comme ingrédient actif un anticorps monoclonal qui réagit avec le facteur de von Willebrand humain qui inhibe l'agrégation plaquettaire induite par ristocétine (APIR), l'agrégation plaquettaire induite par bottrocétine (APIB) et l'agrégation plaquettaire induite par le stress (APIS), et qui ne cause pas de saignement, même lorsqu'il est administré en quantité propre à produire l'effet antithrombotique.
Kito Morikazu
Kobayashi Tsuyoshi
Nagano Mitsuyo
Yamamoto Hiroshi
Yoshimoto Ryota
Ajinomoto Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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