Antithrombotic agents

Details Antithrombotic agents Antithrombotic agents

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/395 (2006.01) A61K 38/05 (2006.01) C07D 205/04 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07K 5/065 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2082748

X-8250A ABSTRACT Thrombin inhibitors represented by the formula Image as provided wherein A is e.g. phenylglycyl, and phenylalanyl, .alpha.-methylphenylalanine and .alpha.- methylphenylglycine wherein the amino group is preferably substituted with lower alkyl alkanoyl or lower alkoxycarbonyl, or a bicyclo group e.g. 1,2,3,4- tetrahydroisoquinolin-1-yl. Also provided are a method for inhibiting clot formation in man and animals, pharmaceutical formulations useful in the method and intermediates for the inhibitors.

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