Antithrombotic and non-hemorrhagic heparin-based...

Details Antithrombotic and non-hemorrhagic heparin-based... Antithrombotic and non-hemorrhagic heparin-based...

A - Human Necessities

61

K

A61K 31/727 (2006.01)

Patent

CA 2198722

Heparin compositions having an antithrombotic activity and virtually no hemorrhagic activity. The object of the invention is to eliminate the risk of bleeding associated with heparins while retaining their main properties. The compositions of the invention (S1, S2, S3) therefore consist of heparin moieties such as those obtainable by the in vitro neutralization of a heparin with a protamine. The invention also concerns a method for the preparation of these compositions which are useful in preparing medicaments.

L'invention concerne des compositions d'héparines présentant une activité antithrombotique et pratiquement dépourvues d'activité hémorragique. Le but de l'invention est de supprimer le risque hémorragique des héparines tout en conservant leurs principales propriétés. A cette fin, les compositions de l'invention (S1, S2, S3) sont constituées de fractions d'héparine telles qu'obtenues par la neutralisation in vitro d'une héparine par la protamine. L'invention concerne également un procédé de préparation de ces compositions. Ces compositions sont utiles pour la préparation de médicaments.

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