C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/083 (2006.01) C07K 5/02 (2006.01) C07K 5/072 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2263732
The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)- aspartyl]-(L)-.beta.-cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes and intermediates for preparing a compound of formula (II) wherein: A, B, Z, E1, E2, G, R, m, n and p are as defined herein.
L'invention concerne une forme cristalline stable non-hygroscopique du composé antithrombotique N-[N-[N-(4-pipéridine-4-yl)butanoyl)-N-éthylglycyl]-(L)-aspartyl-(L)-.beta.-cyclohexyl-alanine amide, procédés pour préparer cette forme cristalline stable, composition pharmaceutique contenant ce composé et formes intermédiaires de ce composé. L'invention concerne en outre les procédés et intermédiaires pour préparer un composé représenté par la formule (I) dans laquelle A, B, Z, E?1¿, E?2¿, G, R, m, n et p sont tels que définis dans le descriptif.
Czekaj Mark
Gardner Charles J.
Klein Scott I.
Molino Bruce F.
Aventis Pharmaceuticals Inc.
Goudreau Gage Dubuc
Rhone-Poulenc Rorer Pharmaceuticals Inc.
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