C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/02 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) C07K 5/072 (2006.01) C07K 5/083 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2174097
The present invention relates to azacycloalkylalkanoyl peptides and pseudopeptides which inhibit platelet aggregation and thrombus formation thereby being useful in the prevention and treatment of thrombosis associated with disease states such as myocardial infarction, stroke, peripheral arterial disease, and disseminated intravascular coagulation, to methods for the prevention or treatment of thrombosis in a mammal in need of such therapy comprising the administration of a therapeutically effective amount of such compounds, and to pharmaceutical compositions comprising such compounds.
La présente invention concerne des peptides ou pseudopeptides à groupe azacycloalkylalcanoyle qui inhibent l'agrégation plaquettaire et la formation de thrombus, ce qui les rend utiles dans la prévention et le traitement de thromboses que l'on rencontre dans des états pathologiques tels que l'infarctus du myocarde, les accidents cérébrovasculaires, les maladies vasculaires périphériques, et la coagulation intravasculaire disséminée. L'invention concerne également des méthodes de prévention ou de traitement de thromboses chez des mammifères nécessitant une telle thérapie, consistant à d'administrer une dose appropriée de tels composés, ainsi que des compositions pharmaceutiques comprenant de tels composés.
Klein Scott I.
Molino Bruce F.
Aventis Pharmaceuticals Inc.
Goudreau Gage Dubuc
Rhone-Poulenc Rorer Pharmaceuticals Inc.
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